Comment on: Pomegranate flower extract does not prevent cisplatin-induced nephrotoxicity in female rats
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pomegranate flower extract does not prevent cisplatin-induced nephrotoxicity in female rats
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متن کاملPomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats
BACKGROUND Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an antioxidant on CDDP-induced nephrotoxicity in female rats. METHODS Twenty-three adult female rats in four groups treated as following. Groups 1 and 2 received PFE at doses of 25 and 50 (mg/kg/day), respectively, for...
متن کاملEffect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats
BACKGROUND Chemotherapy with cisplatin (CP) is accompanied with nephrotoxicity. OBJECTIVES In the current study, pomegranate flower extract (PFE) has been evaluated as an antioxidant agent against CP-induced-renal toxicity. MATERIALS AND METHODS Thirty two male Wistar rats were divided into five groups (6-8 in each group). The animals in groups 1 to 3 received PFE (25 mg/kg), PFE (50 mg/kg)...
متن کاملComment on: effect of pomegranate flower extract oncis platin-induced nephrotoxicity in rats
Implication for health policy/practice/research/medical education: Antioxidant supplements have generally beneficial effects, however, several factors such as the kind of the antioxidant and the dose should be considered to avoid the potential negative effects. Dear editor We read with respect the paper " effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats " by Mota...
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ژورنال
عنوان ژورنال: International Journal of Preventive Medicine
سال: 2015
ISSN: 2008-7802
DOI: 10.4103/2008-7802.158173